A Closer Look at Sonic the Hedgehog
Sonic Hedgehog homolog (SHH) was a term used in one of the three proteins of a hedgehog. It can be found in other types of hedgehog’s including thee mammalian hedgehog family and that of the desert and Indian hedgehog. Sonic Hedgehog is a secreted protein that causes the formation of cell proliferation, differentiation and migration. It acts by binding to other transmembrane.
It was first identified in 1978 on a book by Eric Wieshaus and Christiane Nusslein-Vollhard. The hedgehog genes were identified in the classic Heidelberg screens. Together with scientist Edward B. Lewis, identified the genes and let to the conclusion that these genes where used in the control and segmentation of the fruit fly embryos. During this stage that they found out that the hedgehog loss functions of the mutant phenotype which causes the embryos to be covered small pointy spikes all over its body.







